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Insulin is a hormone that is central to regulating the energy and glucose metabolism in the body. Insulin causes cells in the liver, muscle, and fat tissue to take up glucose from the blood, storing it as glycogen in the liver and muscle.
Insulin stops the use of fat as an energy source. When insulin is absent (or high), glucose is not taken up by body cells, and the body begins to use fat as an energy source, for example, by transfer of lipids from adipose tissue to the liver for mobilization as an energy source.
The lack of insulin results in:
In summary, it is therefore in the insulin deficiency to a substrate defect in the cells to an increase in blood sugar, the water and nutrient loss, to acidification of the blood and to weight loss.
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