The causes of type 1 diabetes is now generally regarded as multifactorial, are owned by both genetic and environmental factors. There are currently more than 20 genes have been identified, one related to the emergence of type 1 diabetes was demonstrated. Most described gene mutations cause a polygenic origin, ie multiple genetic changes must be available to create a type-1 diabetes. Only in rare cases, there is a monogenic disorder.
In particular, genetic modifications of the short arm of chromosome 6, called the MHC region could be held responsible for the development of diabetes mellitus type first The genes HLA-A and HLA include B this region, the genetic information for proteins on the surface of body cells, which are the body’s own immune system as distinctive basis against foreign cells. Play genes outside the HLA complex, presumably a much smaller role in the etiology of type 1 diabetes. Among these is the gene for insulin (INS) and the CTLA4 gene that is responsible for the T-lymphocyte regulation.
To an autoimmune reaction occurs when the immune system an exogenous antigen is exposed, which is similar to a body’s surface protein, or similar. The resulting immune response is directed against both the foreign antigen as well as against the existing body’s proteins on the pancreatic islet cells (Cross, Molecular mimicry). It is further assumed that exposure to foreign antigens, especially in the first months of life has an immunomodulatory effect, which may favor the development of type 1 diabetes. For the following environmental factors could be assigned relationships:
- The consumption of cow’s milk in the first three months of life in children with short breast-feeding.
- The very early exposure to the protein gluten, found in various cereals.
- Diabetic (diabetes inducing) viruses: Coxsackie B viruses (especially B4), intrauterine (in the uterus during pregnancy taking place), rubella infection with the Rubivirus leads (in 50% of diabetes), echo viruses, cytomegalovirus (CMV), herpes viruses.
- Insulin-like structures to solve the antigens of the immune system attack on the pancreas. Lymphocytes from type 1 diabetes demonstrated to react a certain part of the insulin protein.
- Bafilomycin, which are particular to the bad points of root vegetables (potatoes, carrots) is formed by streptomycetes: bafilomycin A1 caused in animal experiments already in nanogram quantities of glucose intolerance and damages the islets of Langerhans in the pancreas. Bafilomycin B1 in pregnant mice also disturbed in a minimal amount of the development of the islets of Langerhans, leading to an increase in the offspring of diabetes first The epidemiology supports the hypothesis Streptomyces: Asians consume far fewer potatoes than Europeans. They suffer significantly less frequently in diabetes.
- Vitamin D supplementation in young children not only helps prevent rickets, but may reduce the subsequent risk of diabetes. Children who had high doses, while the lowest disease risk. Since 1990, the diabetes incidence in a developed countries has nearly doubled. Countries with a low UVB solar radiation have a high rate of new cases.
The following resources may help you:
- Knowing Diabetes Type and What Causes Diabetes
- Diabetes Mellitus Diagnosis and Type of Diabetes
- Manage Diabetes With The Help of Health Professional
- Type 1 Diabetes
- Diabetes and Obesity
- Prevent Diabetes by Understanding Its Causes and Symptoms
- Type 2 Diabetes
- Diabetes Symptoms
- Diabetes and Its Causes
- Diabetes